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HDAC6 inhibitor Ricoliostat: HDAC6 inhibitors can promote the degradation of protein aggregates or protect neurons from oxidative stress, hence can be used as possible drugs for treating peripheral neuropathy

Figure 5 8.5 Current strategies to enhance bioavailability While curcumin demonstrates immense therapeutic promise, its clinical application is significantly hampered by poor bioavailability due to limited absorption, rapid metabolism, and quick systemic elimination

KPV blocks NF-B activation directly inside the cell via the PepT1 transporter, reducing multiple pro-inflammatory cytokines simultaneously without suppressing overall immune function

Effects appear more pronounced in earlier disease stages

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